This guide was developed by the Portland (Oregon) Public Schools to assist district administrators and teachers, grades 9-12, to comply with federal and state mandates to develop and implement a plan for alcohol and other drug prevention instruction. The guide is based on the district-adopted curriculum, "Here's Looking at You, 2000," which includes instruction in three domains: cognitive/information, affective/bonding, and behavioral/skills. Included in the guide is a high school planning matrix and a topic summary, with content areas (physical education, social studies, science, and health) for each topic identified. Recommended learning outcomes are outlined for health education, physical education, social studies, science, and special education. For each content area, additional resources are suggested. The appendices include: the Oregon Administrative Rule which mandates implementation of alcohol and other drug use prevention instruction; a paper, "Risk and Protective Factors for Alcohol and Other Drug Problems in Adolescence and Early Adulthood: Implications for Substance Abuse Prevention"; and a reprinted article, "Knowing What To Do--and Not To Do--Reinvigorates Drug Education." (IAH)