This report outlines the Hillsborough County, Florida, Head Start Program's project to field test with young children and their families curricula that were designed to prevent alcohol and other drug problems. A national search conducted by means of computers, individual contacts, and other methods yielded information on 22 substance abuse prevention curricula. A steering committee evaluated the curricula and chose four programs that they considered to be the most effective for field testing. In a 10-week field test, 193 three- to five-year-olds were exposed to one of the four curricula. The self-concept of the children was measured by the Joseph Pre-School and Primary Self-Concept Test before and after their exposure to the curricula. A project evaluation survey of 181 parents, teachers, and aides was also conducted. It was found that children exposed to each of the four curricula experienced an improvement in self-concept. Among the four curricula, the Preventing the Abuse of Tobacco, Narcotics, Drugs, and Alcohol (PANDA) curriculum of the Chapel Hill Training-Outreach Project proved most effective. Children who were exposed to this curriculum showed a 65 percent improvement in self-concept. The Hillsborough County Head Start Department recommended the implementation of the PANDA curriculum countywide. Contains 37 references. (MDM)