This Maryland resource manual provides local education agencies with guidelines on how to handle body fluids to prevent the transmission of diseases, especially Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV), in the school setting. The first section summarizes the reasons for development of the manual. The second section summarizes the various diseases that are transmitted through blood and body fluids. The third section provides guidelines for school staff on: (1) handwashing; (2) using gloves; (3) disposing of materials soiled with blood and body fluids; (4) identifying diseases that are transmitted via body fluids; (5) cleaning up body fluid spills and the equipment used for cleaning; (6) disinfecting materials and clothes; and (7) educating and training staff. A table lists the body fluid sources (blood, feces, urine, respiratory secretions, vomitus, semen) with the organisms of concern (HBV, HIV, cytomegalovirus, salmonella bacteria, shigella bacteria, rotavirus, mononucleosis virus, cold viruses, influenza viruses, parvovirus, measles, mumps, chickenpox, gonorrhea) and the methods of prevention (using gloves or other barriers, washing hands, reporting accidental contact). The appendices contain diagrams of the correct procedure for handwashing and removing gloves; the Acquired Immune Deficiency Syndrome Education Bylaw; information on understanding the labels of germicides; guidelines on management of exposure to HIV; and a proposed standard for occupational exposure to bloodborne pathogens. (ABL)