This study was undertaken to evaluate Human Immunodeficiency Virus (HIV) prevention and comprehensive health activities in public secondary schools in Mississippi. The Comprehensive School Health Curriculum (CSHC), for implementation in junior, middle, and senior high schools, was designed to promote improved knowledge and behaviors related to the health and well-being of youth. A total of 18 schools participated in the pilot year (1990-91) of curriculum implementation. Evaluation consisted of questionnaires to assess student reaction, learning, and behavior change. A total of 335 usable questionnaires from 8 schools were returned. Results indicate favorable reaction from students; significant differences were found on both the learning and behavior questionnaires between experimental groups of students exposed to the curriculum and control groups. Further analysis reveals that knowledge about safe sex practices does not always translate into safe behavior on the part of the student. Five tables, five figures, a comparison of significant differences between responses of junior and senior high school students, and recommendations for the continuing evaluation of activities comprise 75 percent of the document. (LL)