The primary goal of this Minnesota evaluation project was to identify 20 promising prevention strategies and to evaluate the extent to which school districts utilize these prevention strategies. It was intended that this portrait of how school districts employ effective strategies will inform state policymakers and guide resource development and training. Four data collection methods were used in this project: a literature review, a survey of school principals (N=128), a survey completed by 63% chemical health coordinators, and interviews with chemical health coordinators in 62 of 64 school districts. A stratified random sample of 64 public school districts was drawn, with samples of elementary, middle school, and senior high schools. Key findings include: (1) a systematic review of the social science and health literature yields 26 promising prevention strategies which can be grouped into four areas: promising the values, knowledge and skills of students; promoting positive school climate; empowering parents; and mobilizing communities; (2) the two most widely-employed prevention strategies are self-esteem enhancement and teaching of interpersonal skills; (3) strategies designed to nurture values known to be associated with non-use tend to be underutilized; (4) school district coordinators of alcohol and other drug education advocate increased opportunities for the training of teachers; and (5) only a minority of school districts initiated and implemented efforts to evaluate the quality and impact of prevention programming. (ABL)