The relationship between factors underlying a measure of acculturation, the Acculturation Rating Scale for Mexican Americans (ARSMA), and the 566-item Minnesota Multiphasic Personality Inventory (MMPI) was studied. The ARSMA consists of 20 questions that are scored on a 5-point Likert scale ranging from Mexican oriented (1) to Anglo oriented (5). Acculturation is an important moderator variable in surveys of the mental health of Mexican Americans. Subjects were 349 English speaking Mexican American college students and 101 Anglo American college students in Texas. Results of principal components analysis indicate that noteworthy relationships exist between some aspects of acculturation and conventional measures of psychological adjustment. Individuals who score lower on social withdrawal/intrapersonal dissatisfaction and social conformity on the ARSMA tend to score higher on the social withdrawal/intrapersonal dissatisfaction and social conformity factors of the MMPI. Results are not generalizable to the Hispanic American population as a whole because the sample consisted of English-speaking college students, most of whom were female. Three tables present study data, and there is a 14-item list of references. (SLD)