This Education for Self Responsibility (ESR) curriculum guide is designed as part of an extensive effort to curb the problem of drug use among school-age youth. The guide is designed to help students learn to make intelligent decisions about health and well being and to act responsibly when confronted with opportunities to try drugs. The program focuses on ways in which high school teachers can meet the drug prevention objectives of understanding the consequences, learning the facts, and taking action. Instruction related to these major objectives is facilitated by multiple instructional and behavioral objectives. The educational experiences described here are designed to enable high school teachers to: help students achieve the objectives; empower students to choose not to use drugs; and make all drug use socially unacceptable. The guide is organized into six sections: (1) the Comprehensive Drug Use Prevention Program; (2) Implementing the ESR II Curriculum Guide; (3) Modifying ESR II for Special Populations; (4) Risk Factors for Adolescent Drug Use; (5) Suggestions for Discussion Groups and Speakers; and (6) Sample Lessons for the Prevention of Drug Use. Seven appendices include: Teacher Resources; Annotated Biblioography; Drug Chart; Glossary of Terms; Texas Law Related to Tobacco, Alcohol, and Other Drugs; Agencies and Organizations; and Instructional Strategies and Products for Teaching Drug Use Prevention. (LL)