This Education for Self Responsibility (ESR) curriculum guide is designed as part of an extensive effort to curb the problem of drug use among school-age youth. Three major objectives provide the framework and focus for an instructional emphasis on an alcohol and other drug use prevention program. These objectives are: understanding the consequences, learning the facts, and taking action. Instruction related to these major objectives is facilitated by multiple instructional and behavioral objectives. The educational experiences described here are designed to: enable teachers to help students achieve these objectives; empower students to choose not to use drugs; and make all drug use socially unacceptable in the same way that tobacco use has begun to be viewed negatively in the past few years. The guide is organized into six sections: (1) the Comprehensive Drug Use Prevention Program; (2) Implementing the ESR II Curriculum Guide; (3) Modifying ESR II for Special Populations; (4) Risk Factors for Adolescent Drug Use; (5) Suggestions for Discussion Groups and Speakers; and (6) Sample Lessons for the Prevention of Drug Use. Seven appendices include: Teacher Resources; Annotated Bibliography; Drug Chart; Glossary of Terms; Texas Law Related to Tobacco, Alcohol, and Other Drugs; Agencies and Organizations; and Instructional Strategies and Products for Teaching Drug Use Prevention. (LL)