This Education for Self Responsibility (ESR) curriculum guide is designed to emphasize drug use prevention for prekindergarten-grade 3 students. The program emphasizes good health care practices, safety, personal responsibility, awareness of others, maintaining health, developing positive self-worth, and recognition of roles as family members. The guide is organized into six sections: (1) The Comprehensive Drug Use Prevention Program; (2) Implementing the ESR II Curriculum Guide; (3) Modifying ESR II for Special Populations; (4) Risk Factors for Adolescent Drug Use; (5) Suggestions for Discussion Groups and Speakers; and (6) Sample Lessons for the Prevention of Drug Use. The sample lessons demonstrate age-appropriate ways in which prekindergarten-Grade 3 teachers can integrate good health care practices into the fine arts, language arts, mathematics, science, and social studies curriculums. Seven appendices include Teacher Resources; Annotated Bibliography; Drug Chart; Glossary of Terms; Texas Law Related to Tobacco, Alcohol, and Other Drugs; Agencies and Organizations; and Instructional Strategies and Products for Teaching Drug Use Prevention. (LL)