This guide describes the assistance that modern technology and microcomputers can provide for individuals with significant cognitive disabilities who frequently have secondary physical, communication, or sensory impairments. Applications of technology can be made to increase access to learning for these students in the areas of motor training, mobility, environmental control, communication, and socialization. In addition to helping students become prepared to participate in instruction, technology can assist in delivering instruction. Specific prompting strategies can be employed to teach students how to focus attention on the critical features of the stimulus presented. Systematic reinforcement of correct responses is also important. Effective graphics can be incorporated into computer-assisted instruction and augmentative communication systems. Speech technologies, both speech synthesis and digitized speech, are also being used in instructional applications. The need for customizability of software and hardware is emphasized. A list of 20 readings, 4 organizations, 3 periodicals, and 10 product sources concludes the guide. (JDD)