This handbook, which is the first in a series of materials being developed by an educational group in Albany, New York, for parents and caregivers of preschoolers, focuses on substance abuse prevention concepts. Its goals are to promote awareness that substance abuse prevention starts with very young children and to provide a format of activities for caregivers to implement with young children. Four prevention concepts covered involve: (1) self-concept; (2) decision making; (3) communication; and (4) healthy living. For each of these concepts, four children's activities are described. Activities include cutting out faces that depict different feelings, reading to children, and cutting out magazine pictures of people and food. Appendices include: (1) lists of developmental characteristics of 2-, 3-, and 4-year-olds; (2) an annotated bibliography of children's books relevant to each of the four concept areas; (3) a sample story activity for parent and child; (4) a list of early prevention education materials; and (5) an information sheet about drugs. (BC)