This document is the first in a series of technical reports concerning the high-risk youth demonstration grants of the Office for Substance Abuse Prevention (OSAP). The report summarizes the 130 demonstration grants funded in 1987 to develop, test, and evaluate promising approaches for working with high-risk youth. These approaches involve prevention, intervention, and treatment programs for individuals and groups, as well as comprehensive community-wide projects. The project name, agency, contact, target population, project area, and synopses are included for each grantee. In 56% of the grants, the target population is a minority group. Multiethnic groups that include whites are the target group of an additional 41% of the grants. The etiology of alcohol and other drug use and prevention are discussed, with a review of pertinent research. Summaries describe the models used to reduce the prevalence and incidence of alcohol and other drug problems among specific populations. They also present the outcomes expected by grantees and the contributions being made by each program to the prevention field. Summaries are listed in the following categories: (1) Asian/Pacific Islanders; (2) Blacks; (3) Hispanics; (4) Native Americans; (5) White Americans; (6) multiethnic (minority); and (7) multiethnic (including Whites). Two figures, statistical data on six graphs, and a 157-item list of references is included. (SLD)