A drug abuse prevention curriculum for middle school students in grades five through eight is presented in this document, one of a series that is designed to provide educators with the curricular tools necessary to challenge students to take personal responsibility for their health. Each of the 11 lessons includes information of the lesson objective, class time required, a brief overview of the topic, instructional strategies, teacher materials and preparation, procedures, homework, evaluation materials, and concluding activity. This guide arms middle school students with up-to-the-minute facts on drugs, and engages them in activities that encourage healthy, drug-free choices. Particular consideration is given to tobacco, alcohol and marijuana, including health hazards and societal impacts of their use. The 11-lesson curriculum unit develops students' understanding of the dangers of drug use and encourages the development of decision-making and refusal skills through role playing, cooperative learning groups, oral presentation and research assignments. Students are challenged to identify personal and social factors that influence drug use and non-use. Guidelines are provided for educators to enhance the classroom comfort level when teaching about the prevention of alcohol and other drug use. A glossary of drug terms and a bibliography are included. A separately bound student workbook contains identical exercises and activities for students as those found in the teacher's guide. (ABL)