The Science 16 program provides for the development of essential concepts, skills, and attitudes in science that will enable students to function successfully in the home, classroom, workplace, and community. The program is activity-based, and provides opportunities for students to relate essential concepts, skills, and attitudes to their own world of experience and needs. The approach fosters an appreciation of science for its usefulness and relevance, and motivates students to participate in the learning process. Societal issues involving science and technology have been integrated throughout the program. Community partnerships provide opportunities for students to become involved in the community by way of meaningful activity linked to the science program. Strategies and skills for scientific inquiry, problem solving, and decision making included throughout the Science 16 program provide students with a systematic and logical approach for dealing with a variety of phenomena encountered in their environment. This document contains the program of studies and curriculum guide for the Science 16 program. Contents include chapters which are entitled and adress: (1) "Rationale"; (2) "Philosophy"; (3) "Goals for the Science 16 Program"; (4) "Model for the Science 16 Program"; (5) "Interpersonal Skills and the Social Sphere"; (6) "Required and Elective Components"; (7) "Planning"; (8) "Learning Resources for Science 16"; (9) "Methodology"; (10) "Evaluation"; (11) "Scope and Sequence"; (12) "Program of Studies/Presentation of Content"; and (13) "Suggested Options." (KR)