The validity of American College Testing Program (ACT) test scores and self-reported high school grades for predicting grades in specific college freshman courses was studied. Specific course grades are typically used to place students in remedial, standard, or advanced classes. These placement decisions, in turn, have immediate implications for student performance, satisfaction, and persistence in college. Prediction equations were developed for 18 out of 2,812 specific college courses in English, mathematics, social studies, and natural science using ACT research data from 1980 to 1984 for 233 colleges. The predictive accuracy of these equations was then examined using cross-validation techniques. An additional analysis determined whether the predictive validity statistics varied among types of institutions. Implications of the results for course placement were examined. Eleven tables present study data. Appendix A contains the taxonomy of course codes; and Appendix B contains the cover letter, directions, and questionnaire for the survey of the colleges. (SLD)