The Centers for Disease Control (CDC) has accomplished relatively little in providing Human Immunodeficiency Virus (HIV) education to out-of-school youth. This is because: (1) CDC's Center for Chronic Disease Prevention and Health Promotion (CCDPHP), which has lead responsibility for youth, initially targeted the larger, in-school population; (2) the state and local education agencies funded to serve all youth lacked experience with those out-of-school and the organizations that serve them; and (3) few guidelines or specifically targeted educational materials were available. To overcome these barriers, CCDPHP plans to fund local health departments or community organizations to act as focal points for providing services to out-of-school youth, including HIV education. However, this approach is already being carried out by another center within CDC, the Center for Prevention Services (CPS). Therefore, it is believed the CDC should reassess its current strategy toward reaching high-risk, out-of-school youth, specifically considering whether the out-of-school component of CCDPHP should be merged with CDC's existing prevention programs. (The appendix includes a list of agencies contacted during the review; a list of national organizations targeting out-of-school youth; and a list of non-CDC funded federal programs addressing HIV education for out-of-school youth.) (ABL)