This study examined work and non-workplace sources of stress in the lives of women (N=403) currently employed as health-care providers. Female licensed practical nurses and social workers were sampled because they met the three criteria determined upon for the study; that is, they were all in high-stress occupations; women predominate in those professions; and these professions had readily identifiable populations which permitted drawing random samples. The aim of this longitudinal study was to assess the relationships between work-role quality, family-role occupancy, and family role quality on one hand and mental and physical health outcomes on the other hand. The results indicated that: (1) among female health-care providers, work-role quality was an important predictor of mental and physical health measures, particularly subjective well-being, physical health symptoms, and cardiovascular disease; (2) family role occupancy had few direct effects on psychological distress, well-being, or physical symptoms; (3) parent role and partner role quality had direct, but not interactive effects, with subjective well-being; (4) family role quality had both direct and interactive effects with psychological distress and physical health; (5) the subjects showed stability with respect to role occupancy, role quality, and health measures. Eight tables, and 16 figures are included. (ABL)