The tetrad of subtests of the Wechsler Intelligence Scale for Children-Revised (WISC-R) that best predicts the WISC-R Full-Scale intelligence quotient (IQ) was determined for 1,589 Appalachian students referred for evaluation in grades 1-4, 5-8, and 9-10. The sample was divided into three groups. Students in grades 1 through 4 (n=655) were those with chronological ages (CAs) of 6 years 0 months to 9 years 11 months); students in grade 5 through 8 (n=716) were those with CAs of 10 years 0 months to 13 years 11 months); and students in grades 9 through 10 (n=218) were students with CAs of 14 years 0 months to 16 years 11 months). Students attended three rural county school systems in eastern Kentucky. Stepwise multiple regression analysis was used to ascertain which of the 10 WISC-R subtest scores would be the best tetrad for estimating the full-scale IQ in each age group. Only subtests that were significant at the 0.01 level or less were retained. Results indicate that the picture arrangement, information, block design, and comprehension subtests accounted for 90% of the variance associated with the Full-Scale IQ for grades 1 through 4. The subtests for vocabulary, object assembly, picture arrangement, and coding accounted for 88% of the variance associated with the Full-Scale IQ for grades 5 through 8. The vocabulary, picture arrangement, object assembly, and picture completion subtests accounted for 91% of the variance associated with the Full-Scale IQ for grades 9 through 10. The results indicate that a short version of the WISC-R would be practical, economical, and reliable as a screening instrument for Appalachian students in grades 1 through 10. Three tables show the variables selected by stepwise regression for the age groups. (Author/SLD)