"Skills for Adolescence" is a drug prevention program designed specifically for young adolescents (ages 10 to 14) which features a course for grades 6-8 that can be offered in conjunction with classes in language arts, social studies, health, and related content areas, providing opportunities for students to use the skills of reading, writing, analyzing, and organizing ideas, thinking critically, and communicating with others as they relate to the course topics. This study compared 44 sixth grade students enrolled in this program with a control group of 40 students in a conventional curriculum to assess the positive effects of the "Skills for Adolescence" program on students' self-confidence, general social skills, self-esteem, locus of control, and decision making or problem solving abilities. The study employed nine instruments to test these qualities in both experimental and control groups, before and after the program. Results, based on analyses of covariance and other statistical methods, indicated that the "Skills for Adolescence" program accomplished three of its four evaluated goals: increasing self-confidence, increasing the coping skills of participants, and increasing the number of respondents who exhibited an internal locus of control. The decision-making intervention was the only goal that failed to produce a statistically significant difference. (TE)