The rapid progress in the biological sciences has resulted in many social, ethical, and legal issues. In medical practice, public health programs, research laboratories, law enforcement, insurance, the patenting process, agriculture, genetic counseling, and other fields, legal controversies and public policy debates have developed. Some of these issues entail challenges to traditional interpretations of constitutional principles. This report deals with the implications of new developments in biological sciences as they relate to the freedoms and protections embedded in the Bill of Rights. The chapters are: (1) "Biology and the Constitution"; (2) "Personal Rights and Technological Might"; (3) "The New Biology"; (4) "Human Genetics and the Constitution"; (5) "Public Health Techniques and Technologies"; and (6) "Medical Interventions: The Beginning and End of Life." The appendix contains a list of the Office of Technology (OTA) reviewers, contractors, workshop participants, and external reviewers. Other OTA assessments in progress, related publications, and an order form are included. (RT)