This document presents ALERT, a substance abuse primary prevention program for use with students in grades four, five, and six. The ALERT program is described as promoting higher order thinking skills since each lesson is correlated with Bloom's Taxonomy of Educational Objectives; as providing opportunities for cooperative learning and for significant dialogue between and among students and their teachers; as being "teacher friendly," containing detailed, step-by-step lesson plans, transparencies, student worksheets, and enrichment and evaluation plans; and as requiring no additional class time since the lessons in the curriculum can be integrated into science, health, reading, language arts, social studies, and physical education classes. Included are the five units (20 lessons) of the ALERT program: (1) Health and You; (2) Drugs That Can Help Us; (3) Drugs That Can Harm Us; (4) Recognizing and Resisting Pressures to Use Drugs; and (5) Making Responsible Decisions. Each of the 20 lessons contains a lesson overview; a set of lesson objectives; and sections on time required, materials needs, vocabulary list, teaching procedures, enrichment options, evaluation, and direct instruction. Additional materials and resources are appended. Ready-to-use transparencies are included, as are the transparency masters. (NB)