The Napa Project is a demonstration research study developed to evaluate the effectiveness of seven school-based substance abuse prevention strategies. Various programs were offered to over 7,000 students in grades three through nine. Four programs were delivered to students by regular classroom teachers and two programs were offered as elective courses. These six programs did not address the topic of substance abuse, focusing instead on factors believed to underlie substance abuse (self-esteem and school attitudes). The seventh program was a drug education course which taught students relevant competencies and provided information about the consequences of drug use. Thirteen studies were conducted to evaluate the effects of the individual programs as well as the cumulative effects of several programs delivered to students over a 2- to 3-year period. The results revealed that the drug education course had some positive effects on students' drug knowledge and drug involvement, and their perceptions of peers' attitudes toward drugs and drug use. These effects occurred primarily for girls, and they did not replicate across studies. None of the other programs was found to be effective. The results of these studies question the value of "generic" approaches to substance abuse prevention. This report describes the strategies and discusses the designs, results, and implications of the various studies. Reports on the individual studies are listed in the appendix. (NB)