The goal of this guide is to provide methods and materials that will help students gain the knowledge and skills needed for realistic decision-making regarding Acquired Immune Deficency Syndrome (AIDS) and other sexually transmitted diseases (STD) while emphasizing drug use prevention. AIDS and other sexually transmitted are presented as communicable diseases with the following characteristics: they follow a chain of infection; they need prompt medical care; and they can be prevented. Student activity worksheets and a pre-post questionnaire regarding student knowledge, attitudes, and behavioral intentions are included. The guide contains the following chapters: (1) Why Teach STD's?; (2) How to Use This Guide; (3) Basic Information--Teacher Keys; (4) Student Activities; (5) Evaluation; and (6) AIDS Materials. (MT)