Background information and resources to help K-12 social studies teachers prepare today's youth to cope with the problems that conquering space is sure to bring are provided in this guide. The first part of the guide focuses on political, social, and economic issues that may arise as humans attempt to conquer space. Discussed are the international scene, potential political structures, space revolts, who will go into space, whether there is anyone else out there, the ownership of space, manufacturing in space, and galactic trade restrictions. The second part of the guide contains nine activities dealing with space exploration and conquest that can be used in world history, government, civics, and economics classes. Examples of the activities follow. Students design an international regime, choose space pioneers, decide what role the United Nations should play in human activities in space, and write a constitution for a space colony that has just won its independence from earth. The guide concludes by listing the NASA centers and organizations and publications where teachers can find information about human activities in space. (RM)