The differential reinforcement of other behavior (DRO) is a procedure in which one reinforces an individual when particular behaviors are not emitted for specific periods. This study was designed to determine whether a treatment package consisting of a modified DRO plus momentary restraint and/or noncompliance training could be used to reduce 12 maladaptive behaviors of six school-aged, severely mentally retarded, multihandicapped students. The subjects were treated as three pairs of subjects, each pair of which demonstrated four maladaptive behaviors. The results demonstrated that the treatment package was effective in reducing multiple maladaptive behaviors of the pairs of students even though the same DRO value was used for all four behaviors of each pair at a time. Practical adaptations that help to make DRO procedures more useful for teachers are discussed. (Author/CL)