This teacher's manual is the approved provincial guide for grade 10 science in Manitoba schools. Part 1 (an overview) discusses rationale, learning theory/design, and goals/objectives for the curriculum; design of Science 100 and 101; effects of metric system on the curriculum; special needs students; and student evaluation. Part 2 discusses implementation of the program focusing on curriculum materials, instructional options, alternative approaches to implementation, implementation costs, small schools, role of the guide and support materials, laboratory equipment, and implementation procedures. The next two parts focus on the subject matter of Science 100 and Science 101 respectively. Rationale, basic/supplementary references, and a table of objectives correlated with suggested activities and references are provided for each content area. Design for both Science 100 and 101 includes a "core" or prescribed section and an optional section, providing for flexibility in terms of choice among optional units, teaching approaches, and teaching materials. Sources of curriculum materials used include "Introductory Physical Science (IPS),""Physical Science: An Introductory Study (PSIS),""Individualized Science Instructional System (ISIS)," and "Interaction of Matter and Energy (IME)." A brief description of these materials and a list of process skills fostered in the curriculum are included in appendices. (JN)