Early predictors of two major areas of teenage outcome -- substance use and psychiatric symptoms -- were analyzed and specific developmental paths leading to each teenage outcome were identified in this long-term, follow-up study. Substance "use" rather than "abuse" and psychiatric "symptoms" rather than "illness" were investigated. Interviews were conducted with 939 of the black mothers or mother surrogates who had participated in the 1966-67 Woodlawn study. If mothers consented, their adolescent children were approached for reassessment. A total of 705 black teenagers were reassessed. Through the use of log-linear models and chi-square tests of significance, relationships were sought between measures of first grade social adaptational status (shyness, aggressiveness, learning problems, and cognitive ability), first grade psychological well-being, teenage psychiatric symptoms, and teenage use of cigarettes, marijuana, hard liquor, and beer and wine. Results, including indications of specific paths leading to substance use and to psychiatric symptoms among Woodlawn teenagers and significant sex differences in these outcomes, are discussed. (Author/RH)