As an aid to college administrators, information is presented on the following regulations: (1) Protection of Human Subjects; (2) Title IX of the Educational Amendments of 1972; (3) the Occupational Safety and Health Act of 1970; and (4) Title VI of the Civil Rights Act of 1964. The purpose of the guide is to sensitize administrators to the central issues involved in each regulation and to provide a desk-top reference that will permit judgments as to whether the matter should be pursued. In regard to the regulations on the protection of human subjects, institutions are directed to establish an Institutional Review Committee to determine subject risks, and noncompliance may result in termination of the federal grant or contract. The regulations pertaining to the Educational Amendments of 1972 (prohibiting discrimination in federally-aided educational programs) include the areas of coverage, admission of students, treatment of students, employment, and procedures. In regard to the Occupational Safety and Health Act of 1970, public colleges and universities are excluded from the federal requirements and are only subject to work safety requirements if their states have approved plans. The regulations set extensive standards for programs, materials, and facilities. The purpose of Title VI of the Civil Rights Act was to eliminate widespread discrimination against blacks and other minorities. A bibliography is included. (SW)