The report details the project to develop programed instruction (in which each lesson is programed in small sequential steps) in visual orientation and mobility for multi-impaired low vision children (from preschool age to early adulthood). An introductory section reviews literature showing a need for orientation and mobility instruction; and describes a study to develop, refine, and validate a revised and improved manual in orientation and mobility for multiply impaired blind children. A positive field test with 42 children (4-13 years old) supported the effectiveness of the programed intervention system. A second section focuses on the adaptation of the Peabody Mobility Scale (PMS) for low vision children. A programed instructional system was organized into the same four separate components as the PMS (motor development, vision utilization, concept development, and mobility and orientation skills), and was field tested with 85 visually impaired multiply handicapped children. Ss who received instruction based on the programed intervention system demonstrated significant overall performance gains. Among appended materials are raw data, sample profiles, PMS excerpts, excerpts from programed instructional materials, and sample vision screening and teacher evaluation forms. (SBH)