A change in philosophy for pharmacology instruction for paramedical students required a change to non-traditional methods of instruction. The course consists of five specific and one student-designed unit including objectives, study questions, projects, quizzes, and exams. Multimedia support is discussed, as well as the use of unit directions, study questions, and course projects. Interfacing with the library is essential and methods are explained. Exams are criterion referenced: 85% mastery is required. Final exams are patient-drug case studies, testing ability to apply material mastered. Results indicate a positive change in student attitudes and grade statistics. (Author/VT)