The way in which integrated effort encompassing several epistemologies has developed in one organization is analyzed. The concern is to investigate under what conditions multidisciplinarity flourishes. The data base is a long-term, intensive case study of the Learning Research and Development Center (LRDC) of the University of Pittsburgh since its inception in 1963. Several aspects of the LRDC experience offer themselves as suggestions to others who would seek to construct a multidisciplinary organization. (1) In an environment that contains members of several professions or academic backgrounds, certain safeguards are required for those of "less scientific" fields. (2) There should be frequent attempts at communication among all groups. (3) Joint work is one of the best paths to multidisciplinarity. (4) Certain kinds of professionals and/or certain times in professional careers seem to lend themselves more easily to a multidisciplinary endeavor. (5) Ideal-type roles that embody characteristics of several disciplines can be encouraged as a prototype for the entire environment. (6) Certain organizational characteristics facilitate multidisciplinarity such as placing all groups on the same level in terms of the authority heirarchy or the sharing of personnel and other resources. (7) The multidisciplinary center and the department or school to which a faculty member also belongs must both participate actively in evaluations and decisions regarding promotions or pay raises. (8) Finally, it is necessary that a stable environment be encouraged that provides time and other resources for multidisciplinary knowledge production. (MM)