This manual is the final report on a two-year project to enhance the effectiveness of teaching assistants. It is designed as a workbook for persons conducting instructional programs for teaching assistants and is specific to teaching assistants in engineering and the natural sciences. The manual contains an introduction and six chapters. Chapter one discusses the motivation and beginning processes involved in the project. Chapter two is a list of recommendations for persons beginning similar programs, and chapter three discusses user experiences. Chapter four is a review of selected literature, while chapter five gives a detailed description of the development and use of a teaching assistant survey. The final chapter contains 12 modules designed and used by participants in this project. They are: (1) The Media Show; (2) The Workshop, (3) Enhancing the Effectiveness of a Course Staff; (4) Know Your Audience; (5) Planning by Objective; (6) Initiating Consultation with Faculty; (7) Consulting with Course Staff; (8) Video Taping Teaching Assistants; (9) Problem Solving; (10) Helping Students in Difficulty; (11) Teaching Triads; and (12) Student Evaluation of Teaching Assistants. Each module contains a brief overview, a guide explaining the objective, and a detailed outline of the procedure to be followed. (DMT)