"Of Mice and Men" is developed as an interdisciplinary unit to be team taught by math, science, language arts, and social studies teachers and team guidance counselors. Developed as an individualized program for middle school students, a variety of supplementary materials is provided to exemplify the types of activities suggested for students. Students explore the nature of learning and the nature of intelligence through observation, care, and testing of mice. Building mazes and running tests are major activities of the unit along with intensive observation and recording of learning patterns of mice. Each unit contains an introduction, learning objectives, and activity directions. (Author/JR)