Presented is an annual report of research and supported by the National Eye Institute (NEI) during the 1974 fiscal year. It is explained that the purpose of NEI research programs is to develop scientific knowledge which can be applied to the improved prevention, diagnosis, and treatment of visual disorders. The section on extramural and collaborative programs focuses on research relating to retinal and choroidal diseases, corneal diseases, cataract, glaucoma, and sensory-motor disorders and rehabilitation. Described in the section on intramural research are programs of the Clinical Branch (such as laboratory study of ocular disease in patient); projects of the Laboratory of Vision Research related to biochemistry, experimental embryology, experimental pathology, and neurophysiology; activities of the Office of Biometry and Epidemiology related to diagnostic methods, incidence of disease, identification of risk factors, and comparison of alternative treatments; and public information and program planning efforts. Also included are lists of references or publications (given at the end of each subsection) and a list of intramural research projects. (LH)