Over 100 interactive computer programs for use in general and organic chemistry at the University of Texas at Austin have been prepared. The rationale for the programs is based upon the belief that computer-assisted instruction (CAI) can improve education by, among other things, freeing teachers from routine tasks, measuring entry skills, presenting appropriate material, and conducting simulations. Thus, more flexible, individualized instruction is created. Program development proceeds by breaking a course into units, specifying performance objectives, defining instructional sequences, coding the lesson into computer language and entering it into the machine, debugging it, running a pilot test, and implementing the final version. Programing strategies generally recommend pleasurable interactive sessions of from 20 to 45 minutes. Objectives are specified and then attained through tutorial drill, laboratory simulation, or synthesis programs. A control-experimental design is used for evaluation, with data being compared via techniques such as regression analysis and analysis of variance. Finally, student attitudes toward CAI are checked. (PB)