The basic design for the national evaluation of the Follow Through program is presented, and some of the related issues of analysis are considered. The design, as it now stands, presents many difficulties for analysis. These analysis issues are seen to include the following: (1) What should be the unit of analysis?; (2) How is the effect of a Follow Through approach when compared with its control estimated?; and (3) How is the relative effectiveness of the various approaches estimated? Several different strategies that have been suggested for use in quasi-experiments in attempts to control variables that are confronted with treatments are discussed. The potential confounding variables are classified into two categories: (1) systematic differences in the dependent variable dimensions that are present in the units of analysis at the outset of program participation; and (2) systematic differences that occur in the dependent variable dimensions during program participation which are not a function of program participation. The appropriate method for attempting to control confounding variables in the evaluation of Follow Through appears to be a combination of strategies employing both matching and estimated true score ANCOVE. (DB)