Reported is a review of the literature regarding the relationships of the use of tobacco, especially the smoking of cigarettes, to the health of men and women, primarily in the United States. Topical divisions of the report are: Consumption of Tobacco Products in the United States; Chemical and Physical Characteristics of Tobacco and Tobacco Smoke; Pharmacology and Toxicology of Nicotine; Mortality; Cancer; Non-neoplastic Respiratory Diseases; Cardiovascular Diseases; Other Conditions; Characterization of the Tobacco Habit and Beneficial Effects of Smoking; Psycho-social Aspects of Smoking; and Morphological Constitution of Smokers. Included are summaries and conclusions of the analyses. (BB)