Described is the Anne Sullivan Macy Service for Deaf-Blind Persons, a regional demonstration and research project conducted by the Industrial Home for the Blind in New York and the Social and Rehabilitation Service (DHEW). The purposes of the project are noted to be rehabilitation services to the deaf-blind, mobilization of state and local community resources to initiate referrals for rehabilitation and to provide services following rehabilitation, development of affirmative attitudes by the public toward deaf-blindness, and data collection, research studies, and dissemination of findings. The report describes the deaf-blind, the dimensions of the problem, the rehabilitation program organized, and the approach to cultivating public and professional concern. The salient features of the client group of 171 deaf-blind persons are described, as are the measuring procedures used (observational comparison and followup survey), and the findings of these studies. Recommendations for improving services in the future are made. Appendixes include the schedule of evaluation procedures, characteristics at intake of the clients, changes resulting from rehabilitation in a sample of 50 clients, changes in agency attitudes, a list of publications related to the project, guidelines for volunteers, and descriptions of manual alphabets. (KW)