This document is one of a series describing the background, functions, and utilization of the Regional Information System (RIS), developed by the Michigan-Ohio Regional Educational Laboratory (MOREL). RIS, which was developed to improve the accessibility of information for the educational practitioner, is described in this handbook. The handbook is also designed to help others plan, develop, and operate information systems. Included in the handbook are: (1) an introduction to RIS; (2) a detailed description of the System's two components: the Resource Bank and the Referral Library; (3) information on installation activities; (4) discussions of staffing, facilities, costs, the timetable, and evaluation; and (5) a summary of the evolution of the System. Appendixes include: the Resource Bank coding scheme, the Association Referral Information Service (ARIS) coding scheme, a list of suggested materials for a basic referral library collection, a sample numeric subclassification system, keyword in Context (KWIC) listings, the MOREL search procedure form, a sample data sheet, and an annotated list of selected collections of materials in the MOREL Information Center's information file. (Author/JB)