These guidelines give specific suggestions as to where research resources might be employed to yield greatest returns in terms of usefulness for the formulation and implementation of public policies with respect to the development, allocation, and utilization of human knowledge and skills in our rapidly changing economy. Longitudinal studies are suggested to determine more precisely the kinds of economic, psychological, and sociological problems encountered by the disadvantaged over time, the reasons for their existence, and the most promising policy approach to mitigate and deal with these problems. Eight seminars were conducted for the development of this research guide and related subjects, and the results of these discussions and analysis are included. As a result of their work, four major subject-matter areas were suggested, namely, Human Resources Investment, Supply, Demand, and Market and Mobility. Each of these areas is broken down into specific research topics with an indication of priority, and covering a wide range of material related to economic and non-economic factors. (FP)