Throughout the different phases of a drug development program, randomized trials are used to establish the tolerability, safety and efficacy of a candidate drug. At each stage one aims to optimize the design of future studies by extrapolation from the available evidence at the time. This includes collected trial data and relevant external data.…

A multidimensional Bayesian item response model is proposed for modeling item position effects. The first dimension corresponds to the ability that is to be measured; the second dimension represents a factor that allows for individual differences in item position effects called persistence. This model allows for nonlinear item position effects on…

In light of the replication crisis in psychology, null-hypothesis significance testing (NHST) and "p"-values have been heavily criticized and various alternatives have been proposed, ranging from slight modifications of the current paradigm to banning "p"-values from journals. Since the physics education research community…

Purpose: The paper aims to present a new two stage local causal learning algorithm -- HEISA. In the first stage, the algorithm discoveries the subset of features that better explains a target variable. During the second stage, computes the causal effect, using partial correlation, of each feature of the selected subset. Using this new algorithm,…

The purpose of this study was to conduct a conceptual replication of Pendergast et al.'s (2018) study that examined the diagnostic accuracy of a nomogram procedure, also known as a naive Bayesian approach. The specific naive Bayesian approach combined academic and social-emotional and behavioral (SEB) screening data to predict student performance…

We compared the Wechsler scores of individuals with twice-exceptionality (2e) and giftedness using a three-level Bayesian meta-analysis. Ninety-five effect sizes were calculated from 15 studies (n = 2,106). Results show that individuals with 2e who have learning disabilities perform lower than individuals with giftedness in Full-Scale Intelligence…

The chiropractic clinical competency examination uses groups of items that are integrated by a common case vignette. The nature of the vignette items violates the assumption of local independence for items nested within a vignette. This study examines via simulation a new algorithmic approach for addressing the local independence violation problem…

Changepoints are abrupt variations in a sequence of data in statistical inference. In educational and psychological assessments, it is pivotal to properly differentiate examinees' aberrant behaviors from solution behavior to ensure test reliability and validity. In this paper, we propose a sequential Bayesian changepoint detection algorithm to…

Background: Model-based meta-analysis (MBMA) is increasingly used to inform drug-development decisions by synthesising results from multiple studies to estimate treatment, dose-response, and time-course characteristics. Network meta-analysis (NMA) is used in Health Technology Appraisals for simultaneously comparing effects of multiple treatments,…

Similar estimation biases appear in a wide range of quantitative judgments, across many tasks and domains. Often, these biases (those that occur, for example, when adults or children indicate remembered locations of objects in bounded spaces) are believed to provide evidence of Bayesian or rational cognitive processing, and are explained in terms…

This simulation study was conducted to compare the performances of Frequentist and Bayesian approaches in the context of power to detect model misspecification in terms of omitted cross-loading in CFA models with respect to the several variables (number of omitted cross-loading, magnitude of main loading, number of factors, number of indicators…

Purpose: Scientists in the speech, language, and hearing sciences rely on statistical analyses to help reveal complex relationships and patterns in the data collected from their research studies. However, data from studies in the fields of communication sciences and disorders rarely conform to the underlying assumptions of many traditional…

In this dissertation I argue that truth-conditional semantics for vague predicates, combined with a Bayesian account of statistical inference incorporating knowledge of truth-conditions of utterances, generates false predictions regarding negations and metalinguistic inference. I thus propose a fundamentally probabilistic semantics for vagueness…

Network meta-analysis is becoming a common approach to combine direct and indirect comparisons of several treatment arms. In recent research, there have been various developments and extensions of the standard methodology. Simultaneously, cluster randomized trials are experiencing an increased popularity, especially in the field of health services…

Identifying patterns in the world requires noticing not only unusual occurrences, but also unusual absences. We examined how people learn from absences, manipulating the extent to which an absence is expected. People can make two types of inferences from the absence of an event: either the event is possible but has not yet occurred, or the event…