The Career Adapt-Abilities Scale (CAAS) is one of the most widely used measures to assess career adaptabilities. Despite intensive worldwide use across heterogeneous populations, no study has assessed its factorial validity in the not in education, employment, or training (NEET) population. This study aims to extend evidence of CAAS factorial validity by assessing the Italian version for NEET. Participants (N = 318) completed the Italian CAAS. Confirmatory factor analyses confirmed the hierarchical factor structure of this version. Evidence of measurement invariance across age and sex groups were observed. The results supported the CAAS as a reliable and good psychometrically-based assessment of career adaptabilities in the Italian NEET population.