The research objectives of this study were to study the factors that affect the effectiveness of educational administration of Newly-founded Regional Universities in Guangxi Region, the People's Republic of China, develop and validate the factors and structural equation model of the effectiveness of educational administration, and develop strategies for enhancing the effectiveness of educational administration. A mixed qualitative and quantitative research method was used in 3 research phases. Phase 1 was to study and evaluate the factors that affect the effectiveness of educational administration. Focus Group discussions were conducted in Zhaoqing University with best practice using purposive sampling. Phase 2 was to develop and validate the structural equation model about the factors that affect the effectiveness of educational administration. The sample group consisted of 361 people working in 4 Newly-founded Regional Universities in Guangxi Region, the People's Republic of China, multi-stage random sampling was used. The research instrument was a questionnaire with a reliability value of 0.976. Phase 3 was to develop strategies for enhancing the effectiveness of educational administration. The sample consisted of 6 stakeholders selected by purposive sampling from 4 Newly-founded Regional Universities in Guangxi Region. The instrument used was a semi-structured interview and strategy evaluation by experts. The research results found that: 1) The causal factors included latent variable Organizational Leadership, Faculty Management, Major Development, Student Development, and University-Enterprise Cooperation. And the factor Effectiveness of Educational Administration was the endogenous variables as result. This study had a total of 6 factors, which included 28 indicators. 2) A structural equation model of the effectiveness of educational administration of Newly-founded Regional Universities was established, which was consistent with the empirical data (CMIN/DF = 1.125, p-value = 0.058, RMSEA = 0.019, SRMR = 0.040, CFI = 0.992, TLI = 0.991), and the path coefficients were all significant at the 0.05 or 0.01 level. Latent variable Organizational Leadership, Faculty Management, Major Development, and Student Development had significant and positive effects on enhancing the effectiveness of educational administration of Newly-founded Regional Universities in Guangxi Region, with the total effect coefficients being 0.426, 0.394, 0.322, and 0.327 respectively and 3) The stakeholders from Newlyfounded Regional Universities in Guangxi Region proposed strategies base on the analysis of the model, and the strategies were approved by evaluations of 9 experts of educational administration from Guangxi Region.