The most effective stakeholders of distance education processes are the instructors who carry out and manage the teaching processes. Instructors are expected to master the process in order to carry out distance education effectively and efficiently. One of the most important factors affecting this situation is the satisfaction level of the instructors who gave courses in the distance education process. Thus, this study aims to determine the factors that affect the satisfaction levels of instructors. A satisfaction survey consisting of 11 questions was administered to 741 instructors who gave courses in the distance education process at a Turkish State University. The survey data were analyzed by CHAID method. The findings indicated that the general satisfaction of the instructors was at a good level. Also, it was determined that the suitability of the course for distance education, the willingness to teach online, gender, Internet Access/speed, and age played an important role in instructors' satisfaction levels.