This brief provides guidance to researchers on opportunities to strengthen implementation and student take-up in rigorous studies of college student support interventions. Researchers describe four lessons learned from "Connecting Students to Basic Needs Support: An Evaluation of Single Stop Across Ten Colleges," a RAND study of a college support program. Some of the challenges researchers faced and lessons learned were unique to studies of campus-based college support programs. Other challenges and lessons learned may be more broadly relevant for studies in K-12 settings and for other types of educational interventions (e.g., curriculum changes). RAND researchers conducted an experimental study of Single Stop, a technology-based intervention that leverages screening for public benefits and case management to support low-income college students. Some of the study colleges struggled to implement the program with fidelity, and take-up of the public benefit's screener and case management services was low. The four lessons learned from the Single Stop study may be relevant for researchers to consider as they conduct studies on the impact of student support programs in college settings.