The first gene-targeting studies that examined learning and memory in mice were performed in 1992 (Grant et al. 1992; Silva et al. 1992). The ultimate goal of this new field was to understand the molecular and cellular process underlying normal cognition and how they may be altered in disease states. In the years since these pioneering studies,…

Expression of the immediate-early genes (IEGs) has been shown to be induced by activity-dependent synaptic plasticity or behavioral training and is thought to play an important role in long-term memory. In the present study, we examined the induction and expression of the IEG-encoded protein Egr-1 during an in vitro neural correlate of eyeblink…

Voltage-gated potassium channels (Kv) are critically involved in learning and memory processes. It is not known, however, whether the expression of the Kv1.1 subunit, constituting Kv1 channels, can be specifically regulated in brain areas important for learning and memory processing. Radioactive in situ hybridization was used to evaluate the…

Learning tasks are typically thought to be either hippocampal-dependent (impaired by hippocampal lesions) or hippocampal-independent (indifferent to hippocampal lesions). Here, we show that conditioned taste aversion (CTA) learning fits into neither of these categories. Rats were trained to avoid two taste stimuli, one novel and one familiar.…

We investigated how within-stimulus heterogeneity affects the ability of rhesus monkeys to order pairs of the numerosities 1 through 9. Two rhesus monkeys were tested in a touch screen task where the variability of elements within each visual array was systematically varied by allowing elements to vary in color, size, shape, or any combination of…

In 4 experiments, we examined 16- and 20-month-old infants' understanding of proper names and count nouns. In each experiment, infants were taught a novel word modeled linguistically as either a proper name (e.g., "DAXY") or a count noun (e.g., "a DAXY") for a stuffed animal shown on a puppet stage. This animal was moved to a new location on the…

A female pigtailed macaque ("Macaca nemestrina") with unusual physical characteristics, deficits in learning and cognitive tasks, abnormal social behavior, and abnormal reflexes and motor control was followed from birth until 3 years of age and found to have trisomy 16, which is homologous to trisomy 13 in humans. The animal described here showed…

The field of tissue engineering/regenerative medicine combines the quantitative principles of engineering with the principles of the life sciences toward the goal of reconstituting structurally and functionally normal tissues and organs. There has been relatively little application of tissue engineering efforts toward the organs of speech, voice,…

The author of this article presents his own explanation on the two types of conditioning--respondent and operant. He states that when withdrawal of a negative reinforcer is the contingency that increases the strength of the operant behavior, the stimulus will have a negative emotional response to the experimental chamber. However, when a positive…

This paper is based upon a laboratory exercise designed for biology students in secondary schools or those taking introductory biology laboratory courses in colleges and universities. This exercise requires a set of calipers, a calculator and populations of snail shells collected either from the wild or obtained from a biological supply house. The…

Children's understanding about animal internal structure can be affected by several factors which are poorly understood by teachers. We conducted a large sample study (n=702) of children aged 6-16 years (Grades 1-9) examining children's responses to animals of various size, species and dimensions (2D and 3D objects), and exploring factors which…

This paper evaluated the level of adoption of aquaculture technology extended to farmers in Imo State, Nigeria. To improve aquaculture practice in Nigeria, a technology package was developed and disseminated to farmers in the state. This package included ten practices that the farmers were supposed to adopt. Eighty-two respondents were randomly…

Human cognition is founded, in part, on four systems for representing objects, actions, number, and space. It may be based, as well, on a fifth system for representing social partners. Each system has deep roots in human phylogeny and ontogeny, and it guides and shapes the mental lives of adults. Converging research on human infants, non-human…

The development of visual interaction between mother and infant has received much attention in developmental psychology, not only in humans, but also in non-human primates. Recently, comparative developmental approaches have investigated whether the mechanisms that underlie these behaviors are common in primates. In the present study, we focused…

In this article, the author presents three themes that can form the basis for exciting world language instruction in Spanish, French, and Chinese at any grade level. These three themes (the prehistoric world; endangered species; and space exploration) use basic science as a context for communication that generates student excitement and enthusiasm…