A theory devised initially on the basis of instrumental reward schedule data, such as the PREE, was extended to deal with various Pavlovian findings. These Pavlovian findings include blocking, unblocking, relative validity, positive and negative patterning, renewal, reinstatement, reacquisition, and inhibition. In addition, the sequential model…

The properties of retrograde amnesia after damage to the hippocampus have been explicated with some success using a rat model of human medial temporal lobe amnesia. We review the results of this experimental work with rats focusing on several areas of consensus in this growing literature. We evaluate the theoretically significant hypothesis that…

Research has demonstrated that Long-Evans rats (LER) display superior mnemonic function over Wistar rats (WR). These differences are correlated with endogenous and input-dependent properties of the hippocampus. The present work sought to determine if juvenile pretraining might enhance hippocampal structural markers and if this would be associated…

Gene transcription is essential for the establishment and the maintenance of long-term memory (LTM) and for long-lasting forms of synaptic plasticity. The molecular mechanisms that control gene transcription in neuronal cells are complex and recruit multiple signaling pathways in the cytoplasm and the nucleus. Protein kinases (PKs) and…

Two voluntary task-switching experiments probed the influence of previous exposures to stimuli and categorizations of these stimuli on task choice during subsequent exposures to the same stimuli. Subjects performed origin and size judgments under standard voluntary task-switching instructions to perform the tasks equally often in a random order.…

Across languages, children with developmental dyslexia are known to have impaired lexical phonological representations. Here, we explore associations between learning new phonological representations, phonological awareness, and sensitivity to amplitude envelope onsets (rise time). We show that individual differences in learning novel phonological…

Long-term memory for fear of an environment (contextual fear conditioning) emerges later in development (postnatal day; PD 23) than long-term memory for fear of discrete stimuli (PD 17). As contextual, but not explicit cue, fear conditioning relies on the hippocampus; this has been interpreted as evidence that the hippocampus is not fully…

Previous studies suggested that the beta-adrenergic receptor antagonist propranolol might be a novel, potential treatment for post-traumatic stress disorder (PTSD). This hypothesis stemmed mainly from rodent studies showing that propranolol interferes with the reconsolidation of Pavlovian fear conditioning (FC). However, subsequent investigations…

The role of focusing 4-year-olds' attention on "feeling" or "looking" was examined in three experiments by testing predictions about children's memory for their interactions with an adult partner as they engaged in a collaborative task. Children made collages with an adult partner, and they were later asked to remember who placed the pieces on the…

Temporal distinctiveness models of recency in free recall predict that increasing the delay between the end of sequence and attempting recall of items from that sequence will reduce recency. An empirical dissociation is reported here that violates this prediction when the delay is introduced by the act of recall itself. Analysis of data from a…

The 22q11.2 deletion syndrome (22qDS) and schizophrenia have genetic and neuropsychological similarities, but are likely to differ in memory profile. Confirming differences in memory function between the two disorders, and identifying their genetic determinants, can help to define genetic subtypes in both syndromes, identify genetic risk factors…

Visual scenes contain many statistical regularities such as the likely identity and location of objects that are present; with experience, such regularities can be encoded and can ultimately facilitate the deployment of spatial attention to important locations. Memory-guided attention has been extensively examined in adults with the "contextual…

The amygdala is a key area of the brain where the emotional memories are stored throughout the lifespan. It is well established that synapses in the lateral nucleus of amygdala (LA) can undergo long-term potentiation, a putative cellular correlate of learning and memory. However, a type of short-term synaptic plasticity, known as…

The present study examined whether various indices of interference control were related to one another and to other cognitive abilities. It was found that the interference control measures were weakly correlated and could form a single factor that was related to overall memory performance on the tasks as well as to measures of working memory…

Speakers tend to attenuate information that is predictable or repeated. To what extent is this done automatically and egocentrically, because it is easiest for speakers themselves, and to what extent is it driven by the informational needs of addressees? In 20 triads of naive subjects, speakers told the same Road Runner cartoon story twice to one…