Background/Objective. This study examines the phenomenon of psychological alienation from the perspective of Syrian refugee students in Al-Mafraq Governorate. It explores the impact of variables such as gender, parental presence, duration of asylum, family size, and family income. Psychological alienation is a significant concern for refugee students due to their displacement and the challenges of adaptation. Understanding these factors is crucial for developing effective educational and psychological support programs. Materials/methods. The study utilized a quantitative approach, employing a psychological alienation scale to measure students' levels of alienation. Descriptive statistics, ANOVA, and post-hoc tests were conducted to analyze the differences based on demographic and socioeconomic variables. The sample consisted of Syrian refugee students in the Al-Mafraq Governorate. Results. The findings indicate that the phenomenon of psychological alienation from the perspective of Syrian refugee students in Al-Mafraq Governorate is generally low, with a moderate sense of alienation in certain dimensions, such as loss of belonging and normlessness. No significant differences were found based on gender, parental presence, duration of asylum, or family size. However, family income was a significant factor, with students from lower-income families experiencing higher levels of psychological alienation. Conclusion. The study highlights the role of economic conditions in shaping psychological alienation among refugee students, emphasizing the need for financial and psychological support programs. The results suggest that fostering social integration, providing mental health resources, and improving financial stability can help mitigate feelings of alienation and enhance student well-being.