The swiftly growing field of neurobiological research utilizes highly advanced technologies (e.g., magnetic resonance imaging, electron microscopy) to mediate between investigators and the brains they investigate. Here, the author analyzes a device called the "slam freezer" that quick-freezes neurons to be studied under the microscope. Employing…

CF-1 male mice were trained in an inhibitory avoidance task using a high footshock (1,2 mA, 50 Hz, 1 sec) in order to reduce the influence of extinction on retention performance. At 2, 7, 14, or 30 d after training, the first retention test was performed and hemicholinium (HC-3, 1.0 microgram/mice), a specific inhibitor of high-affinity choline…

In mammals and birds, long episodes of nondreaming sleep ("slow-wave" sleep, SW) are followed by short episodes of dreaming sleep ("rapid-eye-movement" sleep, REM). Both SW and REM sleep have been shown to be important for the consolidation of newly acquired memories, but the underlying mechanisms remain elusive. Here we review…

The neurotransmitter norepinephrine (NE) has been shown to modulate cerebellar-dependent learning and memory. Lesions of the nucleus locus coeruleus or systemic blockade of noradrenergic receptors has been shown to delay the acquisition of several cerebellar-dependent learning tasks. To date, no studies have shown a direct involvement of…

Expression of the immediate-early genes (IEGs) has been shown to be induced by activity-dependent synaptic plasticity or behavioral training and is thought to play an important role in long-term memory. In the present study, we examined the induction and expression of the IEG-encoded protein Egr-1 during an in vitro neural correlate of eyeblink…

There is considerable evidence that encoding and consolidation of memory are modulated by emotion, but the retrieval of emotional memories is not well characterized. Here we manipulated the emotional context with which affectively neutral stimuli were associated during encoding, allowing us to examine neural activity associated with retrieval of…

Observers' judgments of the final position of a moving target are typically shifted in the direction of implied motion ("representational momentum"). The role of attention is unclear: visual attention may be necessary to maintain or halt target displacement. When attention was captured by irrelevant distractors presented during the retention…

Information in the nervous system is conveyed by impulses called action potentials: large, transient electrochemical changes in a neuron's membrane. Though action potentials are a basic feature of neurons, teachers often have trouble explaining this neurophysiological concept, and students have difficulty understanding it. While easy-to-understand…

Recent studies on the anxiety patterns of public speakers have generally supported perspectives on emotion from the field of neurobiology. Without relying on highly invasive or cumbersome technology, much of the biology of speech anxiety has been derived from heart rate studies of physiological arousal rather than examining more direct evidence…

This article presents the argument by the authors regarding the article of Uttal (2004), which lays forth several, rightly justified, caveats in the pursuit of elucidating the neural basis of higher cognitive functions using functional magnetic resonance imaging (fMRI). Adding to the onslaught of criticism from cellular physiologists, Uttal's…

The linguistic and cognitive profiles of five deaf adults with a sign language disorder were compared with those of matched deaf controls. The test involved a battery of sign language tests, a signed narrative discourse task and a neuropsychological test protocol administered in sign language. Spatial syntax and facial processing were examined in…

The use of the "Diagnostic and Statistical Manual of Mental Disorders" (DSM IV) as a teaching tool for social workers to understand mental illness has been debated for many years. The general consensus is that social workers need to be "familiar" with this classification system. Social Work's person in environment perspective, however, requires…

In contrast to "Just Say No" lectures on drug use common in K to 12 drug education programs (e.g., Drug Abuse Resistance Education, or D.A.R.E.), this activity used peer teaching in an Introductory Psychology course to promote active learning and open discussion of controversial issues about drug use. Working in small groups, students researched…

Noting research indicating that the flow of interaction with infants influences their brain development, this viewer's guide and videotape examine characteristics of early brain development and how parents can positively affect the infant's development in a number of areas. The first part of the viewer's guide provides an overview of the…