Artificial intelligence is a tool of the digital economy. Its use facilitates the growth of the level of productivity, effectiveness and quality of managing the spheres of infrastructural support. The smart cities concept is based on ensuring the management of the main city infrastructures based on the means of AI. In the studied countries of Central Asia, the system approach to the regulation of the work market and reduction of the gap between the markets of higher education and work is not used to the fullest extent in the context of the application of AI. However, these countries achieved certain effects in this direction due to the implementation of initiatives connected with the satisfaction of the need for personnel which are required for the performance of new functions and tasks that appeared in the process of digitalisation. In this paper, we determined the universal treatment of the notion of artificial intelligence, formulated in view of the provisions of the main approaches in this sphere and described the features of using artificial intelligence in the management of smart cities in the selected countries of Central Asia in the context of regulation of the work market and closing the gap between the markets of higher education and work. [For the complete volume, "Bridging the Gap between the Higher Education and Labor Markets: Relevance of the Fourth Industrial Revolution. Education in the Asia-Pacific Region: Issues, Concerns and Prospects. Volume 73," see ED676039.]